BioTechnology: An Indian Journal
ISSN (PRINT): 0974-7435

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Tumor And Inflammation Innovations

 Chronic inflammatory mediators exert pleiotropic results within the improvement of cancer. On the one hand, inflammation favors carcinogenesis, malignant transformation, tumor boom, invasion, and metastatic unfold; then again irritation can stimulate immune effector mechanisms that might restrict tumor growth. The link among cancer and irritation relies upon on intrinsic and extrinsic pathways. Both pathways result in the activation of transcription factors which includes NF-κB, STAT-3, and HIF-1 and in accumulation of tumorigenic elements in tumor and microenvironment. STAT-3 and NF-κB engage at a couple of tiers and thereby enhance tumor-associated infection which could suppress anti-tumor immune responses. These elements additionally sell tumor growth, progression, and metastatic spread. IL-1, IL-6, TNF, and PGHS-2 are key mediators of an inflammatory milieu by modulating the expression of tumor-promoting factors.

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Citations : 875

BioTechnology: An Indian Journal received 875 citations as per Google Scholar report

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