7187379870

Research & Reviews in BioSciences
ISSN 0974-7532

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Sickle Cell Disease

Sickle cell disease is a category of disorders that affect hemoglobin, a molecule in red blood cells that provides oxygen to cells in the body. People with this condition have atypical hemoglobin molecules called hemoglobin S, which may shape red blood cells to form a sickle or a crescent. Signs and symptoms of sickle cell disease typically begin in early childhood. Characteristics of this condition include low numbers of red blood cells (anemia), frequent infections, and intermittent symptoms of pain. The frequency of symptoms varies from person to person. Some people have minor symptoms, while others are still treated with more severe complications. Signs and signs of sickle cell disease are caused by red blood cell sickness. If red blood cells have a sickle, they break down prematurely, which can lead to anemia. Anemia can cause shortness of breath, tiredness, and delayed growth and development in children. Rapid breakdown of red blood cells can also cause yellowing of the eyes and skin, which is a symptom of jaundice. Painful episodes can occur when red blood cells, which are stiff and rigid, are trapped in small blood vessels. These episodes deprive oxygen-rich blood of tissues and organs and can lead to organ damage, especially in the lungs, kidneys , spleen, and brain. High blood pressure in the blood vessels that supply the lungs (pulmonary hypertension) is a especially severe complication of sickle cell disease. Pulmonary hypertension occurs in around one third of adults with sickle cell disease and can lead to heart failure.

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