Abstract

Synthesis of some newer 2-substituted-5-methoxyindolyl pyrazolines as potent anti-inflammatory and analgesic agents

Author(s): Ashok Kumar, Trilok Chandra, Neha Garg

2-Substituted-5-methoxy indoles were acetylated to yield 2-substituted-3- acetyl-5-methoxyindoles (1-2). Compounds (1-2) were treated with various aromatic aldehydes to give the corresponding chalcones (3-10). Chalcones were further cyclised with substituted hydrazides to afford the pyrazolines (11-18). The structural assignment of this compounds (1-18) has been made on this basis of elemental analysis,UV,IR, 1HNMR and mass spectral data. All the synthesized compounds (1-18) were screened for their antiinflammatory and analgesic activities at a dose of 50 mg/kg,p.o. The synthesized compound (1-18) were screened for their in vitro anti-inflammatory activity against carrageenan induced rat pawoedema. The compounds were also tested for their analgesic activity against phenylquinone against induced pain syndrome in mice .Compounds 14 and 18 were found to be most active compounds of the series ,which shows 52.8% and 54.6% inflammation inhibitory and 35%and 43.20%analgesic activities respectively.