Abstract

Synthesis of some new coumarin derivatives with biological activity.

Author(s): Satish B.Jadhav, Ranjana A.Shastri, Kishor V.Gaikwad

Two series of coumarin derivatives were synthesized by reacting respectively various 7-Hydroxy chromene-2-one 1a-d with 3-(2-chlorophenyl)-5- methyl isoxazole-4-carbonyl chloride and 3-(2, 4-dichlorophenyl)-5-methyl isoxazole-4-carbonyl chloride to afford a novel biologically more potent compound which is substituted 2-oxo-2H-chromen-7-yl-3-(2-chlorophenyl)- 5-methyl isoxazole-4-carboxylate 2a-d and various substituted 2-oxo-2Hchromen- 7-yl-3-(2,4-dichlorophenyl)-5-methyl isoxazole-4-carboxylate 3ad. All the synthesized products are evaluated for their antibacterial activity against Escherichia coli, Bacillus cirroflagellosus and Salmonella typhi and antifungal activity against Aspergillus niger, Rhizoctonia bataticola and Penicillium. Characterisation of all the compounds has been done by IR, 1H NMR,MS and elemental analysis.All the compounds exhibited significant to moderate antifungal and antibacterial activities.