All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Synthesis of Some New 3-Substituted - 4H-1, 2, 4-triazoles and their Evaluation for Antimicrobial Activity

Author(s): P. K. Goyal, A. Bhandari, A. C. Rana and D. S. Bele

Some new derivatives of 3-substituted -4H-1, 2, 4- triazoles 4 (a-e) were synthesized through the reaction of 4-alkyl diazo substituted 4H-1, 2,4- triazoles- 3-thiole with different aliphatic and aromatic amines to yield the titled compounds. Structure of new compounds were verified on the basis of spectral (UV, IR, 1H-NMR, MS) data and elemental (C, H, N, S) analysis. Antimicrobial activity of all the triazole derivatives were evaluated in vitro against the bacteria S. aureus, B. subtilis, P. aeruginosa, E. coli and fungi A. fumigatus and C. albicans. Most of the compounds showed potent and significant results compared to standard ciprofloxacin and fluconazole.


Share this       
Google Scholar citation report
Citations : 9398

International Journal of Chemical Sciences received 9398 citations as per Google Scholar report

Indexed In

  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Geneva Foundation for Medical Education and Research
  • ICMJE

View More