Synthesis of N-(4-oxo-4,5-dihydro-2-substituted phenyl-3Hthiazolidine-3-yl)-2-(3�?�?-substituted phenyl spiro [3H-indole-3,2�?�?-
thiazolidine]-2,4�?�?(1H)-dione-1-yl)-acetamide

Ashvini Saxena; Ketan H.Sikotra; U.C.Mashelkar

Organic Chemistry: An Indian Journal
ISSN (PRINT): 0974-7516

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Abstract

Synthesis of N-(4-oxo-4,5-dihydro-2-substituted phenyl-3Hthiazolidine-3-yl)-2-(3�?�?-substituted phenyl spiro [3H-indole-3,2�?�?- thiazolidine]-2,4�?�?(1H)-dione-1-yl)-acetamide

Author(s): Ashvini Saxena, Ketan H.Sikotra, U.C.Mashelkar

Startingmaterial 2-(3Ã‚Â’-substituted phenyl spiro [3H-indole-3,2Ã‚Â’-thiazolidine- 1-yl)acetohydrazide have been synthesized according to reported literature which react with different aromatic aldehyde to give NÃ‚Â’-substituted benzylidene- 2(3Ã‚Â’-substitutedphenyl-spiro[3H-indole-3,2Ã‚Â’-thiazolidine]-2,4Ã‚Â’-(1H)- dione-1-yl)acetohydrazide (6a-i). These finally undergo cyclization with thioglycolic acid to give desired compound (7a-i).