Abstract
Synthesis of 8-(1-phenyl-vinyl)-6, 7, 10-trioxa-spiro [4.5] decane and its derivatives
Author(s): Lalit Kumar, Pardeep Kumar, Niranjan Kaushik8-(1-Phenyl-vinyl)-6, 7, 10-trioxa-spiro [4.5] decane is synthetic derivative of Artemisinin (1, 2, 4-trioxane is supposed to be a pharmacophore of Artemisinin) which is a well known antimalarial drug fromleaves ofArtemisia annua find in china. 8-(1-Phenyl-vinyl)-6, 7, 10-trioxa-spiro [4.5] decane and its four different derivatives were synthesized using well standardized method. These compounds were purified by simple column chromatography and successfully analysed using H1NMR, IR and FAB-MS techniques.
