Abstract

Synthesis, molecular modeling and biological activity of zinc(II) salts with 1,4-bis(benzimidazol-2-yl)benzene

Author(s): G.Krishnamurthy

Zinc(II) halides and perchlorate reactwith 1,4-bis(benzimidazol-2-yl)benzene (L) in 1:2molar ratio in n-butanol/2-methoxy ethanol at refluxing temperature to producewhite/pale yellowcolored complexes of the formulae [ZnCl2L]H2O, [ZnBr2L]3H2O and [Zn(OClO3)2L]HOCH2CH2CH2CH3. Zinc(II) iodide also reacts with L in 1:2 molar ratio in n-butanol (HOCH2CH2CH2CH3) to yield white colored complex of the formula [ZnL2(OCH2CH2CH2CH3)2]. The complexes were characterized by elemental analysis, molar conductance measurements, thermal analysis, IR, 1H NMR, 13C NMR spectral studies. The complexes showed significant anthelmintic activity. The minimum energy configuration has been obtained for the zinc complexes using molecular modeling pro plus; a tool developed by ChemSW, Inc, U.S.A.