Abstract

Synthesis, Characterization and Preliminary Antimicrobial Screening of (2z, 4z)-4-(Pyrimidin-2-Ylimino) Pent-2-En-2-Ol (Pip) and its Copper (II) and Chromium (III) Complexes

Author(s): U. S. Oruma, J. N. Asegbeloyin, F. U. Eze and K. F. Chah

The condensation of 2-aminopyrimidine with pentan-2, 4-dione yielded (2Z, 4Z)-4-(pyrimidin-2- ylimino) pent-2-en-2-ol (PIP). Its Cu (II) and Cr (III) complexes were synthesized and characterized via stoichiometric ratio of combination, conductivity measurement, UV/Visible and infrared spectroscopic studies. The ligand was further characterized by elemental analysis, 1H and 13C NMR. Monobasic bidentate coordination of the ligand in the metal complexes was established on the basis of analytical and spectra data. The ligand and complexes were screened for in vitro antimicrobial activity against multiresistant bacterial strains: Escherichia coli (ECO 14 and ECO 6), Pseudomonas aeruginosa (Ps 34) and Staphylococcus aureus (G101 and G72b). The ligand and Cr (III) complex showed activity only on Pseudomonas aeruginosa while the Cu (II) complex was active against the strains of Escherichia coli (ECO6 and ECO14) and Staphylococcus aureus (G101).