All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Synthesis, Characterization and Intramolecular Cyclisation of 5-Substituted Acyclic Nucleosides

Author(s): A. Nura-Lama, M. Bicaj, R. Hoti and A. Musaj

In this paper, synthesis of some new acyclic nucleosides and the intramolecular cyclisation reaction of suitably activated 5-(acetoxymethyl)-1-(2,3-dimethylsulfonyloxypropyl) uracil (4) is described. All compounds were characterised by 1H NMR, 13C NMR and elemental analyses. This intramolecular cyclisation reaction involved nucleophilic attack of the C-2 enoxide ion at the C-2′ rather then at the C-3′ position of the aliphatic chain. The preferred formation of the five-member 2, 2′-anhydro structure was evidenced by the isolation of bicyclical products, 2-methylsulfonyloxymethyl-2,3-dihydro-6- acetoxymethyl-7H-oxazolo [3,2-a]-pyrimidine-7-one (5).


Share this       
Google Scholar citation report
Citations : 9398

International Journal of Chemical Sciences received 9398 citations as per Google Scholar report

Indexed In

  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Geneva Foundation for Medical Education and Research
  • ICMJE

View More