Abstract

SYNTHESIS, CHARACTERIZATION AND ANTI-MICROBIAL ACTIVITY OF NEW SERIES OF BENZOXAZOLE DERIVATIVES

Author(s): G. Balaswamy, P. Pradeep, K. Srinivas and T. Rajakomuraiah

In the present research work, the title compounds were synthesized from 4-hydroxy benzaldehyde (1) on treatment with Al(NO3)3 in the mixture of acetic acid and acetic anhydrides afforded 3-nitro,4-hydroxybenzaldehyde (2), on treatment of 4-hydroxybenzohydrazide gave 4-hydroxy-N'-[(Z)- (4-hydroxy-3-nitrophenyl)methylidene] benzohydrazide (3) and heating with chloramines-T afforded 4-[5-(4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]-2-nitrophenol (4) on reduction afforded 2-amino-4-[5- (4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl] phenol (5) and refluxed with appropriate aliphatic acid yielded the corresponding 4-[5-(2-substituted-1,3-benzoxazol-5-yl)-1,3,4-oxadiazol-2-yl] phenol. The identification and characterization of all the synthesized compounds were confirmed by elemental analysis, melting point, thin Layer Chromatography, FT-IR, 1 H NMR and mass spectral data. All the compounds were screened for antimicrobial activity. In view of interesting biological activities and pharmacological importance associated with benzoxazole derivatives hence, some of the derivatives of benzoxazole containing heterocyclic ring have been prepared and their bio-potential have been evaluated.