Abstract

Synthesis, Characterization and Antimicrobial Screening of 4-[4-Pyridinecarboxylic) Diamino]-4-Chlorobenzoyl)-3-Methyl-1-Phenylpyrazol-5-One and Its Ni (II), Cr (III), Cu (II) And Co (II) Complexes

Author(s): J. N. Asegbeloyin, N. N. Ukwueze, I. C. Agbo and U. S. Oruma

A 4-acylpyrazol-5-one Schiff base with isoniazide moiety; 4-[4-pyridinecarboxylic) diamino]-4- chlorobenzoyl)-3-methyl-1-phenylpyrazol-5-one was synthesized by condensation of 4-chlorobenzoyl-3- methyl-1-phenylpyrazol-5-one with pyridinecarboxylic acid hydrazide. The ligand was characterized on the basis of elemental analysis, infrared (IR), 1 H and 13C NMR data. Ni (II), Cr (III), Cu (II) and Co (II) complexes of the ligand were also synthesized. The metal complexes were characterized by elemental analysis, molar conductance, magnetic measurements, IR and electronic spectral studies. All the synthesized compounds were screened for their in vitro antimicrobial activity against some Gram-positive and Gram-negative clinical bacterial strains. Antimicrobial activity test results revealed that the compounds showed better activity against the Gram-positive bacterial strains.