Abstract

Synthesis, characterisation and antimicrobial activity of some novel 3[-(3-(4-flourophenyl)-1-isopropyl indole-2-yl) allyl) piperazin-1-yl] 1, 2-benzisothiazole and derivatives

Author(s): Kishor V.Gaikwa, Shantilal D.Rathod, Sanjay B.Sawant, Dadaso V.Kale, Satish B.Jadhav, Sandip V.Gaikwad

Series of newheterocyclic compounds viz. 3-[-3-(3-(4-flourophenyl)-1-isopropyl indole-2-yl) allyl) piperazin-1-yl] 1, 2-benzisothiazole (5a-h) have been synthesized by the interaction of substituted 3-[3-(4-flourophenyl)-1- isopropyl indole-2-yl] acrylaldehyde (4a-h) with 3-(piperazin-1-yl) 1,2- benzisothiazole to obtained a biodynamic heterocyclic moiety (5a-h) with enhanced biological activity.All the synthesized products are evaluated for their antibacterial activity against Staphylococcus aureus, Bacillus pumilis, Escherichia coli and Proteus vulgaris and antifungal activity against Aspergillus niger, Aspergillus flavus, Penicillium Chrysogenumand Fusurium moneliforme. Characterisation of all the compounds has been done by IR, 1H NMR,MS and elemental analysis.