Abstract
Synthesis and spectral characterization of potential impurities of tiaprofenic acid
Author(s): Ramadas Chavakula, M.Narayana Rao, K.Praveen Kumar, Ch.Srinivas Rao, B.Gopi Babu,R.V.Nageswara RaoDuring the process development of tiaprofenic acid (1). Two impurities A&C with respect to tiaprofenic acid were detected by in-house method of simple reverse phase high-performance liquid chromatography (HPLC). Two impurities A&C have been prepared. The 1H and 13C NMR data of impuritiesA&C were reported in this paper for the first time. Based on the spectral data, the structure of these impuritiesA&C were characterized as (5-Ethylthiophen-2-yl)phenylmethanone and (2RS)-2-(5-benzoylthiophen- 3-yl) propanoic acid. The synthesis, characterization of these impurities were discussed.
