Abstract
Synthesis and reactions of some novel triazolo-, azolo-, tetrazolopyridopyrimidine and their nucleoside derivatives
Author(s): Kh.M.Abu Zied, A.B.A.El-Gazzar, N.A.HassanPyridopyrimidine react with aldehyde afforded the arylhydrazone (2a,b) which could be cyclized into the pyrido[2,3-d][1,2,4]triazolo[4,3- a]pyreimidine (3a,b), andwith formic acid, acetic acid and carbondisulphide to give pyrido[2,3-d][1,2,4]traizolo[4,3-a]-yrimidine (4,5). Reaction of (1) with nitrous acid afforded tetrazolo[1,5-a]pyrido[2,3-d]-yrimidine (6),which was reduced by zinic dust to give 2-amino-pyrido[2,3-d]pyrimidine 7. Finally the reaction of 2-hydrazino 1 with D-zyloxe or D-glucose afforded the acyclic N-nucleoside (8,11) which were converted into tetra/penta Oacetate acyclic C-nucleoside (9,12) in acetic anhydride/pyridine. Deactylation of compounds (9,12) afforded C-nucleosides (10,13).
