Abstract

Synthesis and characterization of some novel derivatives of 6-fluoro-3-[3-(4-fluorophenyl)-1-isoproplyl indol-2-yl) allyl] piperidine-4-benzisoxazoles possessing good anti-inflammatory and antimicrobial activity

Author(s): Shantilal D.Rathod, Kishor V.Gaikwad, Sandip V.Gaikwad, Satish B.Jadhav

The synthesis of a series of substituted 6-fluoro-3-[3-(4-fluorophenyl)-1- isoproplyl indol-2-yl) allyl] piperidine-4-benzisoxazole described which are novel and obtained in excellent yield. Substituted 3-(4-flourophenyl)-1-isopropyl indole 3a-h on condensationwith acrolein gives substituted 3-[3-(4- flourophenyl)-1-isopropyl indole-2-yl] acrylaldehyde which on again condensation with another active pharmaceutical ingredient i.e. 6-fluoro-3-(piperidine- 4-yl) benzisoxazole which is neuroleptic active to give another biologically more potent compound which is substituted 6-fluoro-3-[3-(4- fluorophenyl)-1-isoproplyl indol-2-yl) allyl] piperidine-4-benzisoxazole 5ah. All these novel compounds 5a-h have been characterized by spectroscopic means and have been screened for anti-inflammatory and antimicrobial activity.