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Abstract

Synthesis and Characterization of 2-Carbamazepinyl 4- Quinazolone and 6, 8- Dibromo-2-Carbamazepinyl-4-Quinazolone

Author(s): V. Niraimathi, K. Kesavan and C. Vamsadhara

A simple, efficient and general method has been developed for the synthesis of 2-hetero substituted -4-quinazolones by using Niementowski reaction. The synthetic reaction involves thermal condensation and cyclisation of a drug amide with anthranilic acid and 6, 8–dibromo anthranilic acid at elevated temperatures to yield the hetero-moieties namely carbamazepinyl –4–quinazolone and 6, 8- dibromo-2-carbamazepinyl-4-quinazolone. The structures of the compounds were characterized by IR, NMR, MS and elemental analysis. The compounds were evaluated for antimicrobial activity.


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  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Geneva Foundation for Medical Education and Research
  • ICMJE

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