Abstract
Synthesis and biological screening of 2-(4ﾃｯﾂ?ﾂ｢-chlorophenyl)-6-methyl-3-(3ﾃｯﾂ?ﾂｲ- aryl -1ﾃｯﾂ?ﾂｲ-acetyl/phenyl -4ﾃｯﾂ?ﾂｲ,5-dihydropyrazol-5ﾃｯﾂ?ﾂｲ-yl)- imidazo[1, 2-a]pyridines
Author(s): V.V.Bhuva, V.N.Patolia, A.U.Patel, D.M.Purohit2-(4ﾃδｯﾃや堙つ｢-chlorophenyl)-6-methyl-3-(3ﾃδｯﾃや堙つｲ-aryl-1ﾃδｯﾃや堙つｲacetyl-4ﾃδｯﾃや堙つｲ,5ﾃδｯﾃや堙つｲ-dihydropyrazol-5ﾃδｯﾃや堙つｲ- yl)imidazo [1,2-a] pyridines (4a-4l); 2-(4'-chlorophenyl)-6-methyl-3-(3ﾃδｯﾃや堙つｲ-aryl- 1ﾃδｯﾃや堙つｲ-phenyl-4ﾃδｯﾃや堙つｲ,5ﾃδｯﾃや堙つｲ dihydropyrazol-5ﾃδｯﾃや堙つｲ-yl) imidazo [1, 2-a] pyridines(5a-5l) have been synthesized. The products have been assayed for their biological activity against Gram +ve,Gram ﾃ窶堙や砺e bacteria and fungi. Some of the products showed moderate activity in concentration 50ﾃδｯﾃつﾃつｭg/ml. The structures of the products have been elucidated by IR, 1HNMR, Mass spectral data, elemental analysis and thin layer chromatography.
