Abstract

Synthesis and antimicrobial activity of novel substituted thaizole-2-semicarbazides and its derivatives

Author(s): Suliphaladevara Mathada Basavarajaiah, Bennikallu Hire Mathada Mruthyunjayaswamy

Substituted-thiazole-2-semicarbazides (3a-b) on reactionwith ethyl acetoacetate/ ethylcyanoacetate/ acetylacetone/carbon disulphide-potassium hydroxide and different substituted aromatic acids in presence of phosphorous oxychloride yielded the corresponding 3-methyl-N-(4-substituted-1’3’- thiazol-2’-yl)-5-oxo-4,5-dihydro-1H-pyrazole -1-carboxamides (4a-b)/3-amino- N-(4-substituted-1’3’-thiazol-2’-yl)-5-oxo-4,5dihydro-1H-pyrazole-1- carboxamide (5a-b)/3,5-dimethyl-N-(4-substituted-1’3’-thiazol-2’-yl)-1Hpyrozole- 1-carboxamide (6a-b)/5-[(4-substituted-1’,3’-thiazol-2’-yl)amino]- 1,3,4-oxadiazole-2(3H)-thione (7a-b)/2-(substituted)-5-[(4-substituted-1,3- thiazol-2-yl)amino]-1,3,4-oxadiazole (8a-h) respectively. Structures of the all the newly synthesized compoundswere confirmed by spectral data.All these compounds have been screened for their antimicrobial activity.