Abstract

Synthesis and antibacterial activity of substituted indolylthiadiazole derivatives and substituted quinazolinonylthiadiazole derivatives

Author(s): Indu Singh, K.K.Sexana, Arun Kumar, Ashok Kumar

Amixture of 6-(bromomethyl)-5-(pyridin-4-yl)- [1,2,4] triazolo [3,4-b] [1,3,4] thiadiazole (3) with 2-substituted alkyl/aryl-5-substituted-3-amino indoles give 2-(substituted alkyl/aryl)-5-(substituted) -N- [3-(pyridin-4-yl)methyl]- 1Hindol-3-amino- [1,2,4] triazolo [3,4-b] [1,3,4] thiadiazoles (4a-4j). 2-substituted- 3- [3-(pyridin-4-yl)-6 / 6,8-substituted methyl amino] quinazolin- 4(3H)-one- [1,2,4] trizolo [3,4-b] [1,3,4] thiadiazoles (5a-5l) have been synthesized by 6-(bromomethyl)-5-(pyridin-4-yl)- [1,2,4] triazolo [3,4-b] [1,3,4] thiadiazole (3)with 2-substituted 6 / 6,8-substituted 3-amino quinazolinones. All the synthesized compounds were screened for their antibacterial activity and compared with reference drugs ampicillin and gattifloxacin. The compound (4i) was the most potent compound of this series. Structure of all the synthesized compounds have been characterized by elemental (C, H, N) and spectral (IR and 1H NMR) analysis.