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Abstract

Synthesis and Antibacterial Activity of Some Chalcone Derivatives

Author(s): B. Jayachandra Reddy and M. C. Somasekhara Reddy

In an effort to develop antibacterial agents, a few chalcones were prepared by aldol condensation of appropriate acetophenones with appropriate aromatic aldehydes in the presence of aqueous potassium hydroxide and ethanol at room temperature. Then novel chalcone derivatives were prepared further by coupling with methyl 4-(1-(aminomethyl)cyclopentyl)benzoate (7), which is prepared via Grubbs metathesis. The structures of compounds (i-iv) were elucidated on the basis of spectral and chemical studies. All the compounds were tested for their antibacterial activities by the paper disc method.


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  • Geneva Foundation for Medical Education and Research
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