All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Study of the Binding Ability of Molecular Imprinted Solid Phase Extraction for Glibenclamide by Optimizing Template : Monomer : Crosslinker Ratio

Author(s): Aliya Nur Hasanah, Tridessy Nanda Sari, Natalia Wijaya, Rahmana Emran Kartasasmita and Slamet Ibrahim

Five molecularly imprinted polymer for glibenclamide was prepared by using glibenclamide as the template, acrylamide as the functional monomer and ethyleneglycoldimethacrylate as a cross linker in different ratios. Binding ability analysis showed that acetonitrile pH 4 is the best solvent for rebinding of the analyte. The imprinting factor (IF) was calculated by comparing the retention of glibenclamide on the imprinted polymer with a comparable non-imprinted polymer. The template : monomer : crosslinker ratio of 1:6:70 resulted in an IF of 6.85. This MIP has the potential for use in SPE for purification and concentration of glibenclamide and with further optimization.


Share this       
Google Scholar citation report
Citations : 9398

International Journal of Chemical Sciences received 9398 citations as per Google Scholar report

Indexed In

  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Geneva Foundation for Medical Education and Research
  • ICMJE

View More