Abstract

Study of micellar behaviour of SDS and CTAB in aqueous medium containing Trammadol Hydrochloride - A narcotic analgesic drug

Author(s): Poonam Sharma

Conductance and Viscosity studies of anionic surfactant SDS (Sodium dodecyl sulfate) and cationic surfactant CTAB (Cetyltrimethylammonium bromide) have been carried out in aqueous solutions of Trammadol Hydrochloride (0.001 and 0.01M) in the temperature range 20 – 40oC. From conductance measurements, the critical miceller concentration (CMCÂ’s) of SDS and CTAB has been determined in the above said aqueous Trammadol Hydrochloride solutions. From CMC data, various thermodynamic parameters viz. standard enthalpy change for micellization (Ho m), standard entropy change for micellization (So m) and standard free energy change for micellization (Go m) have been evaluated. The work has also been extended to include the viscosity studies of SDS and CTAB in aqueous solutions of drug in order to calculate relative viscosity (çr). All these parameters have been discussed in terms of drug – drug, drug – solvent and drug – surfactant interactions as a consequence of various electrostatic and hydrophobic interactions.