Abstract
Stereoselective aminomethylation of m-cresol with chiral amine mediated by 4Ã?Â? molecular sieves under neat conditions
Author(s): Mostafa GholizadehA minomethylation at ortho position with respect to hydroxyl group of mcresol in presence carefully dried 4Å molecular sieves under neat conditions. One pot, two component,Mannich reaction of m-cresol with imine at 600C temperature under solvent free conditions affords the corresponding aminomethylated products in good yields, with moderate stereoselectivity.
