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Abstract

Stability Indicating HPLC Method for Determination of Rimonabant

Author(s): Y. Padmavathi, P. Hari Krishna and B. Madhava Reddy

A simple, inexpensive and rapid, stability indica ting isocratic HPLC method has been developed for the quantitative determination of rimonabant, an anti-obesity drug. Degradation studies were performed on the bulk drug by heating to 105°C, exposure to UV light at 254 nm, acid (0.1 N hydrochloric acid), base (0.1 N sodium hydroxide) and aqueous hydrolysis and oxidation with 3.0 % v/v hydrogen peroxide. Considerable degradation was observed under oxidation conditions. Good resolution between the peaks corresponding to impurities produced during synthesis, degradation products and the analyte was achieved on Ace-C18, 150 x 4.0 m.m column using a mobile phase consisting of a mixture of aqueous potassium dihydrogen phosphate and acetonitrile. Validation of th e method was carried out as per ICH requirements.


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Citations : 9398

International Journal of Chemical Sciences received 9398 citations as per Google Scholar report

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  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Geneva Foundation for Medical Education and Research
  • ICMJE

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