Abstract

Spectrophotometric estimation of ofloxacin in bulk drug and pharmaceutical dosage forms

Author(s): P. B.Mohite, R.B.Pandhare, S.G.Khanage, V.H.Bhaskar

Two simple, precise and economical spectrophotometricmethods have been developed for the estimation of Ofloxacin in bulk and pharmaceutical formulations. Ofloxacin shows a sharp peak at 302.0 nmin first order derivative spectrum with n =1(MethodA). Ofloxacin also shows a zero absorbance at wavelength 320.0 nm, which is, based on zero crossingmethod (Method B). The drug follows Beer-Lambert’s lawin the concentration range of 2-20g/ ml in both the methods. Results of the analysis were validated statistically and are found satisfactory.