Abstract

Spectrophotometric determination of flavoxate hydrochloride in bulk and pharmaceutical formulation

Author(s): K.Siddappa, Mahesh Tambe, Mallikarjun Metre, Tukaram Reddy, Mallikarjun Kote

Two simple, rapid and sensitive extractive spectrophotometricmethods have been developed for the determination of flavoxate hydrochloride (FLH) in pure and pharmaceutical formulations. These methods are based on the formation of chloroform soluble ion-association complexes of FLH with bromothymol blue (BTB) and with bromophenol blue (BPB) in potassium phthalate-HCl buffer of pH 3.6 (MethodA) and glycine-HCl buffer of pH 3.0 (Method B) with absorption maximum at 417 nm and 411 nm respectively. Reaction conditions were optimized to obtain themaximumcolor intensity. The absorbance was found to increase linearly with increase in concentration of FLH, which was corroborated by the calculated correlation coefficient values (0.9996 and 0.9995). The systems obeyed Beer’s law in the range of 2–20 g/ml and 1–25 g/ml forMethodAand B respectively. Various analytical parameters have been evaluated and the results are validated by statistical data. No interference was observed from common excipients present in pharmaceutical formulations. These proposed methods were simple, accurate and suitable for routine quality control applications.