Abstract

Some new thioxopyrimidinones, thiazolopyrimidinone derivatives using diary epoxypropanones as precursor as potential antimicrobial agents

Author(s): R.Eman Kotb, M.Nabil Yousif, A.M.Maher El-Hashash,A.M.Mowafia Salama, A.M.Nayera Abdelwahed, S.Hemat Khalaf

3-(4-chlorophenyl)-1-(2-naphthayl)-2,3-epoxypropanone (2) react with thiourea and urea to give 4-(4-chlorophenyl)hexahydro-6-(2-naphthyl)-2- thioxopyrimidine-5-one (3) and 4-(4-chlorophenyl)hexahydro-6-(2- naphthyl)pyrimidine-2,5-dione (4) respectively. Reaction of (3) with each of bromoacetic acid and 2-bromopropionic acid produced thiazolo[3,2- a]pyrimidine-3,6-diones (5) and 2-methyl-thiazolo[3,2-a]pyrim- idine-3,6- dione (6) successively. Also some new derivatives (7-14) were prepared fromthe reaction of compounds (3) and (5)with different reagent. Compound (3) was glycosidated with chloroethyl methyl ether and 2-chloroethanol to afford compound (15) and (16); newly synthesized compounds were tested for their antimicrobial evaluation. Among the assayed compounds derivatives (14a), (3), (8b), (8c) and (14b) showed the highest effect compared with the other tested compounds but not more than the satandered.