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Abstract

Simultaneous Spectrophotometric Estimation of Atorvastatin Calcium and Amlodipine Besylate in Combined Tablet Dosage form by First Order Derivative Method Method

Author(s): Dharmesh J. Jani, Satishkumar A. Shetty, Manzoor Ahmed, B. K. Sridhar and Jignesh S. Shah

The objective of the current study was to develop a simple, accurate, precise and rapid UV spectrophotometric method with subsequent validation using ICH suggested approach for the determination of atorvastatin calcium (ATR) and amlodipine besylate (AML) using methanol as the solvent. The proposed first order derivative method involves the measurement of absorbances of one drug at zero crossing point of other; 237.5 nm and 247 nm was selected for the estimation of ATR and AML. The linearity of the proposed method was investigated in the range of 5-50 μg/mL (r = 0.9996) for ATR and 5-50 μg/mL (r = 0.9999) for AML, resptectively. The percentage mean recovery was found to be 100.23% for ATR and 100.07% for AML. Also the method was statistically validated for its linearity, accuracy and precision. Both inter-day and intra-day variations were found to be showing less % RSD value indicating high grade of precision of this method.


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Citations : 9398

International Journal of Chemical Sciences received 9398 citations as per Google Scholar report

Indexed In

  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Geneva Foundation for Medical Education and Research
  • ICMJE

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