Abstract

Serum glutathione-S-transferases activity in esophagus cancer patients receiving chemotherapy

Author(s): N.R.Hazari, R.S.Ambad, A.P.Thorat

Purpose: - To analyze the level of serum glutathione-s-transferases (GSTs) activity in patients with esophagus cancer. Methods: - For the study total 50 cases of carcinoma of esophagus of stage II and stage III (receving chemotherapy) were selected. All patients were clinically and histological diagnosed. 40 age and sex matched healthy normal subjects selected as control. GSTs activity was measured in the serum of control group (n=40) and in patients with esophagus cancer (n=50). Results: -Mean GSTs activity in serumwas significantly higher in patients with esophagus cancer as compared to control group (p<0.001). The patients of stage III of esophagus cancer had significantly elevated activity of serum GSTs than stage II. Conclusion: - Measurement of serum GSTs activity may be useful as a tumor marker in esophagus cancer.Alterations in serumGSTs levels might be helpful to predict the response of chemotherapy.