Abstract

Self aggregation of a selective serotonin reuptake inhibitor drug paroxetine hydrochloride: A thermodynamic study

Author(s): Muhammad Asghar Jamal*, Khurram Shahzad, Ali Bahadur

Paroxetine HCl is an amphiphilic serotonin specific reuptake inhibitor antidepressant drug. The association characteristics, thermodynamic behavior and sonochemical behavior of this drug in ethanol have been determined fromdensity and ultrasound velocity data at 298.15 Kand 308.15 K using an Anton Paar density sound analyzer (DSA 5000). The critical micelle concentrations of this drug were obtained from ultrasound velocity measurement by using recently developed least square fitting algorithm. The compressibility data have been used to discuss solvent-aggregate interaction.