All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Selective N1-Alkylation of 1,3-Dibenzoylquinazoline-2,4(1H,3H)-Dione with Benzyl Chloride

Author(s): Ozerov AA and Novikov MS

The reaction of 1,3-dibenzoylquinazoline-2,4(1H,3H)-dione with potassium carbonate in anhydrous DMF at room temperature leads to the formation of a potassium salt of 3-benzoylquinazoline-2,4(1H,3H)-dione, the alkylation of which in situ with benzyl chloride produces 1-benzyl-3-benzoylquinazoline-2,4(1H,3H)-dione. A one-pot method for the preparation of N1-monosubstituted derivatives of quinazoline-2,4(1H,3H)-dione was developed. The effect of an alkaline agent on the yield and ratio of the debenzoylation products was studied.


Share this       
Google Scholar citation report
Citations : 9398

International Journal of Chemical Sciences received 9398 citations as per Google Scholar report

Indexed In

  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Geneva Foundation for Medical Education and Research
  • ICMJE

View More