Abstract

Role of Photo Dynamic Therapy in Cancer Treatment

Author(s): Chloe Wilson

Photodynamic therapy (PDT) is a minimally invasive, clinically approved therapeutic treatment that has the ability to selectively kill cancer cells. The technique begins with the introduction of a photosensitizing agent, followed by irradiation at a wavelength that corresponds to the sensitizer's absorbance band. In the presence of oxygen, a number of events occur that result in direct tumor cell death, microvascular damage, and the initiation of a local inflammatory response. PDT has been shown to be curative in clinical trials, especially in early-stage cancers. It can help patients with inoperable malignancies live longer and have a better quality of life. This treatment has little normal tissue toxicity, minor systemic effects, significantly reduced long-term morbidity, no innate or acquired resistance mechanisms, and excellent cosmetic and organ function sparing effects. It is an important therapeutic alternative for patients receiving several treatments.