Rapid generation of N,N�?�?�?�?�?�?�?�?-diacylhydrazines by I2 or Br2/hydrazine hydrate: A facile route to 1,3,4-oxadiazoles

Malavath Geeta Pamar; Ramesh Gannimani; Patrick Govender; Deresh Ramjugernath; Hemmaragala Marishetty Nanjundaswamy

Organic Chemistry: An Indian Journal
ISSN (PRINT): 0974-7516

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Abstract

Rapid generation of N,N�?�?�?�?�?�?�?�?-diacylhydrazines by I2 or Br2/hydrazine hydrate: A facile route to 1,3,4-oxadiazoles

Author(s): Malavath Geeta Pamar, Ramesh Gannimani, Patrick Govender,Deresh Ramjugernath, Hemmaragala Marishetty Nanjundaswamy

We report the rapid preparation of symmetrical aldazines, ketazines and N,NÂÃ‚Â’-Diacylhydrazines byNH2NH2 .H2O in presence ofmolecular iodine or bromine at 0ÂÃ‚Â–10ºC. This method afforded an exceedingly convenient route to the preparation of 1,3,4-Oxadiazoles. The reactions are safe, affording excellent yields of high purity products in shorter durations and the workup procedure involves no solvent extraction, which is environmentally acceptable.