Abstract
Preparation of 2-(N-substituted carboxamido methyl thio) -5-([4-(4-chloro benzylidine) amino phenyl]-1,3,4- oxadiazoles
Author(s): Hitesh P.Shah1,3,4-Oxadizoles form a biologically important group of compounds having activities like analgesic, anti-inflammatory, bactericidal, antifungal, anticonvulsant, psychotropic, plant growth regulating andmono amino oxidase inhibition. This research has focused on the incorporation of the oxadiazole moiety into isoniazid because of their versatile biological action, to get 2-(Nsubstituted carboxamidomethyl thio) -5-([4-(4-chloro benzylidine) amino phenyl]- 1,3,4- oxadiazole to explore the possibilities of some altered biological action. The synthesized compounds were characterized by Melting point, Thin layer chromatographyInfra red, Nuclear magnetic resonance spectroscopy, etc. Almost all the synthesized compounds possessed good activity as compared to the standard.
