Abstract

Physicochemical Studies of Metal Complexes of Drug Diazepam (7-Chloro-1-methyl-5-phenyl-3H-1, 4-benzodiazepine-2-one) in Solid State

Author(s): Neeraj Sharma

Thermogravimetric analyses have been used to evaluate kinetic parameters of metal complexes of diazepam. The thermal decomposition of metal complexes of diazepam drug is kinetically of zero order and the activation energy for the decomposition process lies in the range of 4-14 kcal mol-1. I R spectra indicate that the metal complexes exist with monomeric structure through metal nitrogen bonding of 1, 4- N atom of ligand molecule.