Abstract

Microwave assisted synthesis and characterization of some new triazole derivatives

Author(s): T.Vijay kumar, Amol Y.Ghodke, N.Kashinath, B.N.Poul

The reaction of 4-chlorobenzoic acid (1) with thiocarbohrdrazide (2) by fussionmethod to get 4-amino-5-(4-chlorophenyl)-4H-1,2,4-triazole-3-thiol (3). Treatment of compound (3) with various aromatic aldehydes in presence of dry benzene to yield 4-(benzylidene amino)-5-(4-chlorophenyl)- 4H-1,2,4-triazole-3-thiol (4a-e) respectively. which on reaction with acetyl chloride and triethylamine in presence of dry benzene afforded 1-[3-(4- chlorophenyl)-5-mercapto-4H-1,2,4-triazol-4-yl]-4-phenylazetidin-2-one (5a-e). The purity of the compounds was checked by TLC. All newly synthesized compounds were characterized on the basis of IR, 1HNMR, mass spectral data and elemental analysis.