Abstract

Microwave assisted synthesis and antibacterial activity of some piperidine containing pyrimidine imines and thiazolidinones

Author(s): Ram C.Merugu, D.Ramesh, B.Sreenivasulu

1-(4-(4-piperidin-1-yl)phenyl)ethanone on condensation with aryl aldehydes afforded 1-(4-(4-piperidin-1-yl)phenyl)-3-substituted phenylprop- 2-en-1-one (1a-e) in good yields which underwent cyclization with guanidine hydrochloride (2) furnished 4-phenyl-6-(4-(piperidin-1-yl) substituted phenyl)pyrimidin-2-amine (3a-e) followed by condensation of (3a-e) with benzaldehyde (4) yielded N-benzylidene-4-phenyl-6-(4-(piperidin-1-yl) substituted phenyl)pyrimidin-2-amine (5a-e). The cyclo condensation of compound (5a-e) with mercapto acetic acid (6) gave 2-phenyl-3-(4-phenyl- 6-(4-(piperidin-1-yl)substituted phenyl)pyrimidine-2-yl)thiazolidin-4- one (7a-e) in appreciable yields. All the reactions have been carried out under microwave irradiation. The structures of the above synthesized newcompounds were established by spectral data.All the new compounds have been screened for their antibacterial activity.