Abstract

Microwave assisted synthesis and antibacterial activity of 2-(4-phenyl-6-(4-(piperidin-1-yl) aryl substituted) pyrimidin-2-yl) isoindoline-1, 3-diones

Author(s): Ram C.Merugu, D.Ramesh, B.Sreenivasulu

1-(4-(piperidin-1-yl) phenyl) ethanone (3) has been synthesized by the reaction of piperidine (1) with 4-chloro acetophenone (2) in the presence of dry acetone under microwave irradiation. 1-(4-(piperidin-1-yl) phenyl) ethanone (3) on condensation with aryl aldehydes (4a-e) afforded 3-phenyl- 1-(4-(piperidin-1-yl) aryl substituted) prop-2-en-1-one (5a-e) in good yields which underwent cyclization with guanidine hydrochloride (6) furnished 4-phenyl-6-(4-(piperidin-1-yl) aryl substituted) pyrimidin-2-amine (7 a-e). The treatment of compound (7a-e) with phthalic anhydride (8) in the presence of catalytical amount ofDMF undermicrowave irradiation yielded 2-(4-phenyl-6-(4-(piperidin-1-yl) aryl substituted) pyrimidin-2-yl) isoindoline- 1,3-diones (9a-e). All reactions have been carried out under microwave irradiation. The structures of the above synthesized new compounds were established by spectral data. All the new compounds have been screened for their antibacterial activity.