Abstract

Microwave assisted efficient synthesis of (Pyrimido[4, 5- e][1,3,4]thiadiazin-7-yl) hydrazine derivatives

Author(s): Mohammad Kazem Mohammadi

An efficient and mild technology for the synthesis of (pyrimido[4, 5- e][1, 3, 4]thiadiazin-7-yl)hydrazine compoundswas described via themicrowave assisted cyclocondensation of alkyl-2-phenylhydrazinecarbodithioates as bidentate nucleophileswith 5-bromo-2,4-dichloro-6-methylpyrimidine and further replacement of chlorine atomof pyrimido[4, 5- e][1, 3, 4]thiadiazin by hydrazine under microwave irradiation. These compounds are prepared under microwave irradiation versus conventional heating in high yields and short reaction times.