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Abstract

Method development and validation of silymarin in bulk and pharmaceutical formulation by UV- spectrophotometric area under curve method (AUC)

Author(s): Sandip D.Firke, Nikhil Patel, Sanjay J.Surana, Sunjaykumar B.Bari

A new, simple, rapid and novel UV- spectrophotometric method has been developed for estimation of Silymarin (SLY) by using Area under Curve method (AUC). Themethod involved measurement of absorbance at wavelengths 288 nm for measurement of area under curve in the wavelength range 265.60 – 311.80 nm for SLY. Linearity was observed in the concentration range of 5-25 µg/ml, with correlation coefficient value 0.9985. The proposed method was recommended for routine analysis since it is a rapid, simple, accurate, sensitive and specific. The results obtained are reproducible with a coefficient of variation less than 2%. This method was validated for precision, reproducibility, linearity and accuracy as per ICH guidelines.


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Citations : 378

Analytical Chemistry: An Indian Journal received 378 citations as per Google Scholar report

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