Abstract

In Vitro Antioxidant Activity of Various Extracts of Whole Plant of Bridelia ScAndens (Roxb) Willd

Author(s): D. Senthil Kumar, A. Kottai Muthu, D. Satheesh Kumar and R. Manavalan

The objective of this investigation was to evaluate the in vitro antioxidant activities of various extracts of whole plant of Bridelia scandens. All the three extracts were examined for DPPH (
,
- diphenyl-β-picrylhydrazyl) radical scavenging activity, superoxide anion scavenging activity and iron chelating activity with reference standard rutin, quercetin and EDTA, respectively through in vitro models. The methanolic extract of Bridelia scandens was found to be most active than that of other two extracts of Bridelia scandens in scavenging DPPH radicals with rutin used as reference standard and an IC50 value was found to be 90 µg/mL and 480 µg/mL, respectively. Scavenging superoxide radical and iron chelating activity of the three extracts were carried out with quercetin and EDTA as reference standards. Both the methods significantly showed the methanolic extract of Bridelia scandens was most effective than that of petroleum ether and ethyl acetate extracts. It is concluded that the methanolic extract of Bridelia scandens showed strong scavenging activity against free radical as compared to all other extracts.