Abstract

Identification, isolation, characterization and synthesis of novel impurity in antipsychotic drug: Aripiprazole

Author(s): Madhusudhan Gutta, Chandrababu Kollapudi, D.Chandrasekhar, V.Balraju, R.Buchi Reddy

During the process development of aripiprazole (1) in our lab, one unknown impuritywas detected inHPLCanalysis at levels ranging from0.05 to 2.0%. The unknown impurities have not been reported previously in the preparation of aripiprazole as a bulk drug synthesis. This impuritywas isolated, synthesized and characterized as 7-(4(4-(2,3-dichlorophenyl) piper azin-1-yl)butoxy)quinolin-2(1H)-one, by 1H NMR, IR and mass spectral data.