Abstract

Hepatoprotective Activity of Momordica Cymbalaria Hook. F against Paracetamol Induced Hepatic Injury in Rats

Author(s): B. M. Vrushabendra Swamy and K. N. Jayaveera

Methanolic extract of Momordica cymbalaria Hook. F. (MEMC) was studied against paracetamol induced hepatitis in rats. Alteration in the levels of biochemical markers of hepatic damage like SGPT, SGOT, ALP, bilirubin, cholesterol, HDL, tissue GSH and lipid peroxidation were tested in both; treated and untreated groups. Pre-treatment with MEMC reduced biochemical markers of hepatic injury like SGPT, SGOT, ALP, bilirubin, cholesterol and lipid peroxide levels and increased HDL, GSH levels. Treatment with MEMC (200, 400, 600 mg/kg) has brought back the altered levels of biochemical markers to the near normal levels in the dose dependent manner. A significant hepatoprotective activity of the methanol extract of Momordica cymbalaria has been reported.