Abstract

Formulation and In vitro characterization of Ketorolac loaded Nanosponges

Author(s): R Gangadhara*

Topical gel preparations are intended for skin application or to certain mucosal surfaces for local action or transdermal penetration of medicament or for their emollient or protective action. The aim of the present study is to formulate ketorolac nanosponge loaded topical gel. For this purpose, ketorolac was entrapped in nanosponge and incorporated into gel and evaluated. By solvent evaporation method, using β cyclodextrin and ethyl cellulose Ketorolac Nanosponges was formulated. The particle size and entrapment efficiency was found below 620 nm and below 98.42 % respectively. Based on its particle size and entrapment efficiency, F6 formulation was optimed and further loaded into topical gels using guar gum, Xanthan gum & HPMC K4M and evaluation tests was performed which reveals satisfactory results. From the drug release studies, F6K6 formulation containing guar gum with higher proportions shows 96.07% of drug release at the end of 11hrs & follows zero order kinetics.