Abstract

Formulation and Evaluation of Ramipril Transdermal Patch

Author(s): P. Dwarakanadha Reddy, D. Swarnalatha, A. Dinakar, P. Naresh Babu, C. Raghunath Guptha, C. H. Venku Reddy, B. Sravani, S. Shankar Rao and B. Sudheer Chowdary

Transdermal patch are self contained discrete dosage forms, which when applied to the intact skin, deliver the drug through the skin at controlled rate to the systemic circulation. Ramipril transdermal patch was prepared by acrylic (2-ethylhexyl acrylate) based polymer. Methyl acrylate (monomer), vinyl acetate (copolymer) in ethanol as solvent and ramipril was dissolved or suspended in mixture of solvents constituted by one litre of propan -2-ol and 1.5 liter of ethyl acetate. The mixture was stirred, until a homogeneous mass was obtained, and this was evaporated. The composite medicated foil form the final transdermal patch. Evaluation was done by physical appearance, folding endurance, water vapour transmission, drug diffusion study, permeability studies, content uniformity and in vitro drug release.