Abstract

Formulation and Evaluation of Nimesulide Hibiscus Esculentus Fruit Mucilage Matrix Tablets

Author(s): Hindustan Abdul Ahad, B. Pradeep Kumar, C. Haranath and K. Somasekhar Reddy

The main aim of the present study was to develop matrix tablets of nimesulide with Hibiscus esculentus fruit mucilage and to study its functionality as a matrix forming agent for sustained release tablet formulations. Physicochemical properties of dried powdered mucilage of Hibiscus esculentus mucilage were studied. Various formulations of nimesulide Hibiscus esculentus mucilage were prepared. They were found to have better uniformity of weight and drug content with low SD values. The swelling behavior and release rate characteristics were studied. The dissolution study proved that the dried Hibiscus esculentus mucilage can be used as a matrix forming material for making sustained release tablets.