Abstract

Five spectrophotometricmethods for determination of sulpride in pure formand pharmaceutical dosage form

Author(s): KhalidAbdel-SalamM.Attia, NasrM.El-Abasawy, AhmedM.Abdelraoof

Five Simple, rapid, sensitive, accurate and precise stability-indicating spectrophotometric methods were developed for the determination of sulpride in bulk powder and in pharmaceutical preparation. Method (A) First derivative method(1D), Method (B) Ratio derivative method(1DD), Method (C) Ratio difference method, Method (D) Bivariate method and Method (E) Dual wavelength method are used for the determination of intact sulpride in presence of its degradation product. The methods were validated and successfully applied to the determination of Dogmatil ® 50mg tablets. The obtained results were statistically compared with those of the reported method by applying t-test and F-test at 95% confidence level and no significant difference was observed regarding accuracy and precision.