Abstract

Fabrication and Evaluation of Glimepiride Ficus Benghalensis Fruit Mucilage Matrix Transdermal Patches

Author(s): Hindustan Abdul Ahad, B. Pradeep Kumar, C. Haranath and K. Somasekhar Reddy

The main purpose of the present study was to develop matrix type transdermal patches of glimepiride with Ficus benghalensis fruit mucilage and to study the permeability patterns. Transdermal patches were prepared by solvent evaporation technique. The prepared patches were evaluated for physicochemical characteristics viz. thickness, mass and drug content, which were uniform in prepared batches. The study proved that glimepiride can be developed as a transdermal patch with Ficus benghalensis fruit mucilage. In vitro permeation studies were performed using rat abdominal skin as the permeating membrane in Keshary-Chien cell