Abstract

Effect of fuzheng paidu tablet on immune function of immunosuppressive mice induced by cyclophosphamide

Author(s): Weiyun Xin, Ming Bai, Shuo Tian, Jiaojiao Jia, Mingsan Miao

Objective: To explore the effect of Fuzheng Paidu tablet on cyclophosphamide(CY) induced immunosuppressed mice immune function. Methods: with mushrooms polysaccharide as positive control mice, inhibit the immune function of model induced by cyclophosphamide, observe the high, middle and low dose of Fuzheng Paidu tablet (Fuzheng Paidu-HD, Fuzheng Paidu-MD, Fuzheng Paidu-LD)on immunosuppressive mice induced by cyclophosphamide, the influence of macrophage phagocytic percentage and phagocytic index of hemolysin and hemolytic plaque forming and influence of lymphocyte transformation. Results: Cyclophosphamide immunosuppression model was successfully created. Compared with the model group, high, middle and low dose of Fuzheng Paidu tablet could significantly improve the inhibition of mouse peritoneal macrophage phagocytic percentage, phagocytic index of cyclophosphamide induced immunity, and could promote the formation of hemolysin and hemolysis and the transformation of lymphocyte (P<0.01), Fuzheng Paidu-HD had the strongest effect. Conclusion: Fuzheng Paidu tablet has good improvement effect on immune function of mice induced by cyclophosphamide low